Endocrine Abstracts

Introduction: Insulinoma is a rare neuroendocrine tumor. 90% of insulinoma is solitaire and benign, and 10% is malignant. Although seen at any age, it is most commonly noticed in 4th and 6th decades.Case: A 78-year-old man was referred to a neurology clinic upon a sudden faint, disability to remember and meaningless behavior, and diagnosed with epilepsy in 2008. In 2012, he had a hypoglycemia attack (blood glucose 30 mg/dl) and was referred to Ege Univer...

Introduction: Wolfram syndrome has characterized by central diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA) and deafness. In this report we presented a Wolfram syndrome with hypergonadotropic hypogonadism.Case: A 18-year-old girl who has diabetes for 6 years was hospitalized due to blood sugar irregularity. Her medical history revealed frequent urination and enuresis for 2–3 years and primary amenorrhea. Furthermore she had hear ...

Introduction: 46 XX male syndrome generally presented as hypogonadotrophic hypogonadism.Case report: A 39-year-old man was referred to our clinic with a pituitary mass. He had a history of pituitary adenoma of 45×28×40 mm size which was found after his admission with right-sided vision loss at 2006. The hormonal analyses showed hypogonadotrophic hypogonadism without any excess hormone levels. A transcranial pituitary adenomectomy was performed....

Pregnancy in active acromegaly at reproductive age is very rare occurrence due to hyperprolactinemia, hypogonadism and side effects of treatment of acromegaly. Only a few reports were described in medical literature by now.We report a 31-year-old woman ongoing active acromegaly despite who received Octeatide LAR 30 mg treatment monthly for the control of GH and IGF1 excess until realized her pregnancy. A GH secreting pituitary macroadenoma (tumor size 2 ...

Introduction: Immunocytochemistry methods have demonstrated that most of the ‘clinically non functional’ adenomas are actually gonadotrophin secreting adenomas or gonadotroph adenomas. Gonadotroph adenomas are discovered in patients presenting with visual field disorder. Pituitary imaging almost always demonastrates macroadenoma. Anterior pituitary insufficiency is much more frequent than gonad hyperstimulation. Herein, we present six cases of FSH and/or LH positive ...

Introduction: The most common cause of diabetes insipidus is idiopathic. However, it may be also seen after metastasis to hypothalamic–pituitary region.Case: Fifty year old female patient with breast cancer was referred to our clinic with complaints of polyuria and polydipsia. Two years ago, she had diagnosed and after surgery, she has taken three cycles of cyclophosphamide+adriamycin+5-flurourasil than three cycles dosetaxel and finally seventeen c...

Lingual thyroid is an abnormal formation appearing as the result of a deficient descent during embryological development of the thyroid gland through the thyroglossal duct to its normal pretracheal location, and it is a rare embryological aberration. A 19 years old woman was admitted to with foreign-body-feeling, dysphonia, hoarseness, constipation. Examination showed a spherical, red fleshy and smooth contoured mass rat back of the tongue. Thyroid scan with technetium 99 m re...

Primary mediastinal ectopic goiters are very rare and comprise about 1% of all mediastinal tumors. Blood supply of primary mediastinal goiter comes from local intrathoracic vessels. Compressing symptoms, diagnostic uncertainty, and the risk of malignancy support surgical excision.Case report: The patient is a 40-year-old woman with a 6-month history of progressive dyspnea, chest and back pain. Chest X-ray showed the left superior mediastinal mass was com...

Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. It is usually seen in children and young adults.The thyroid gland is diffusely involved. It is characterized by scattered microscopic tumor islands, diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammom body when compared with conventional papillary thyroid carcinoma. Usually the lesion does not cause mass but rather a dominant nodule in one lobe is present in 50% of cases. Ly...

Background: Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas dimension (> 2 cm), CK19 status, tumor staging and grading (Ki67 > 2%), and age of onset (> 50 years) can be considered elements of suspect.Case presentation: We report a case of malignant insulinoma in a 80 year old woman presenting symptoms c...